Phage-antibiotic combinations to control Pseudomonas aeruginosa–Candida two-species biofilms
https://www.nature.com/articles/s41598-024-59444-2
The use of phage-antibiotic combinations to treat bacterial infections is getting more attention. These combinations often have stronger effects when used together. However, most studies focus on treating one type of bacteria, even though infections can involve multiple species. This study aimed to see how phage-antibiotic and phage-antifungal combinations work on biofilms formed by P. aeruginosa and the fungus Candida albicans. We found that a phage combined with ciprofloxacin could reduce P. aeruginosa biofilms. We also found that the phage and the antifungal fluconazole could work against younger dual-species biofilms (formed by P. aeruginosa and C. albicans). However, it didn’t work well on older biofilms. This study is a starting point for potential ways to treat infections caused by both bacteria and fungi using phage-antibiotic combinations.
PHAGElogist 